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Infect Immun. 2009 Dec;77(12):5428-36. doi: 10.1128/IAI.00528-09. Epub 2009 Sep 21.

Characterization of a Campylobacter jejuni VirK protein homolog as a novel virulence determinant.

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1
Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut 06536, USA.

Abstract

Campylobacter jejuni is a leading cause of food-borne illness in the United States. Despite significant recent advances, its mechanisms of pathogenesis are poorly understood. A unique feature of this pathogen is that, with some exceptions, it lacks homologs of known virulence factors from other pathogens. Through a genetic screen, we have identified a C. jejuni homolog of the VirK family of virulence factors, which is essential for antimicrobial peptide resistance and mouse virulence.

PMID:
19797067
PMCID:
PMC2786475
DOI:
10.1128/IAI.00528-09
[Indexed for MEDLINE]
Free PMC Article
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