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Curr Opin Cell Biol. 2009 Dec;21(6):855-63. doi: 10.1016/ Epub 2009 Sep 30.

Growth control and ribosome biogenesis.

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Department of Molecular Biology and NCCR Program Frontiers in Genetics, University of Geneva, 30 quai Ernest-Ansermet, Geneva 4, Switzerland.

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  • Curr Opin Cell Biol. 2010 Aug;22(4):555.


Ribosomes provide the basis for protein production and this drives cell growth. Recent studies, both in yeast and in higher eukaryotes, are beginning to reveal new mechanisms underlying the elaborate control of ribosome biogenesis, which requires coordinate regulation of all three RNA polymerases. Transcription of ribosomal RNA is finely tuned to cellular energy status and linked to the production of ribosomal proteins. Several autoregulatory mechanisms controlling various aspects of ribosome biogenesis have been uncovered and reveal new connections to cell-cycle and cell-size control. Ribosome biogenesis has now been clearly linked to disease, particularly to cancer and anemia, and also to aging. A challenge for future studies will be to elucidate further the molecular mechanisms underlying these connections.

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