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Nat Rev Neurol. 2009 Oct;5(10):528-9. doi: 10.1038/nrneurol.2009.154.

Multiple sclerosis. TNFRSF1A, TRAPS and multiple sclerosis.

Author information

1
Institute of Clinical Neuroimmunology-Campus Grosshadern, Ludwig Maximilians University of Munich, Marchioninistrasse 15, Munich, Germany. tania.kuempfel@med.uni-muenchen.de

Abstract

A genome-wide association study has identified the R92Q variant of the TNFRSF1A gene as a new susceptibility locus for multiple sclerosis. This locus is of special interest because the R92Q substitution was previously detected in a group of multiple sclerosis patients who had additional symptoms compatible with the autoinflammatory syndrome TRAPS.

PMID:
19794511
DOI:
10.1038/nrneurol.2009.154
[Indexed for MEDLINE]

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