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Phys Med Biol. 2009 Oct 21;54(20):6277-86. doi: 10.1088/0031-9155/54/20/016. Epub 2009 Oct 1.

A quantitative assessment of the depth sensitivity of an optical topography system using a solid dynamic tissue-phantom.

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Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK.


A solid dynamic phantom with tissue-like optical properties is presented, which contains seven discrete targets impregnated with thermochromic pigment located at different depths from the surface. Changes in absorption are obtained in response to localized heating of the targets, simulating haemodynamic changes occurring in the brain and other tissues. The depth sensitivity of a continuous wave optical topography system was assessed successfully using the phantom. Images of the targets have been reconstructed using a spatially variant regularization, and the determined spatial localization in the depth direction is shown to be accurate within an uncertainty of about 3 mm down to a depth of about 30 mm.

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