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Physiol Meas. 2009 Nov;30(11):1211-25. doi: 10.1088/0967-3334/30/11/006. Epub 2009 Oct 1.

A subspace decomposition approach toward recognizing valid pulsatile signals.

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Neural Systems and Dynamics Laboratory, Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.


Following recent studies, the automatic analysis of intracranial pressure (ICP) pulses appears to be a promising tool for the prediction of critical intracranial and cerebrovascular pathophysiological variations during the management of many neurological disorders. A pulse analysis framework has been recently developed to automatically extract morphological features of ICP pulses. The algorithm is capable of enhancing the quality of ICP signals, recognizing valid (not contaminated with noise or artifacts) ICP pulses and designating the locations of the three ICP sub-peaks in a pulse. This paper extends the algorithm by proposing a singular value decomposition (SVD) technique to replace the correlation-based approach originally utilized in recognizing valid ICP pulses. The validation of the proposed method is conducted on a large database of ICP signals built from 700 h of recordings from 67 neurosurgical patients. A comparative analysis of the valid ICP recognition using the proposed SVD technique and the correlation-based method demonstrates a significant improvement in terms of (1) accuracy (61.96% reduction in the false positive rate while keeping the true positive rate as high as 99.08%) and (2) computational time (91.14% less time consumption), all in favor of the proposed method. Finally, this SVD-based valid pulse recognition can be potentially applied to process pulsatile signals other than ICP because no proprietary ICP features are incorporated in the algorithm.

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