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J Child Neurol. 2009 Dec;24(12):1561-3. doi: 10.1177/0883073809334384. Epub 2009 Sep 30.

Successful treatment with sumatriptan in a case with cyclic vomiting syndrome combined with 18q- syndrome.

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Department of Pediatrics, Tohoku University School of Medicine, Sendai, Miyagi, Japan.


The authors present a 14-year-old girl with 18q- syndrome combined with cyclic vomiting syndrome. Since the age of 5 years, she has been admitted to hospital 30 times. Despite trying many prophylactic treatments, no medication has inhibited the vomiting attacks successfully. Intranasal sumatriptan was effective at halting the vomiting attacks. This is the first case of 18q- syndrome combined with cyclic vomiting syndrome successfully treated with sumatriptan. This report may allow us to consider sumatriptan use in patients suffering from misery attack of cyclic vomiting syndrome combined with chromosomal abnormality of 18q- syndrome.

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