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Mol Biol Cell. 2009 Dec;20(23):4976-84. doi: 10.1091/mbc.E09-04-0295. Epub 2009 Sep 30.

Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells.

Author information

1
Institut National de la Santé et de la Recherche Médicale, U823, Institut Albert Bonniot, Université Joseph Fourier, F-38706 Grenoble, France.

Abstract

A major regulatory function has been evidenced here for HSF1, the key transcription factor of the heat-shock response, in a large-scale remodeling of the cell epigenome. Indeed, upon heat shock, HSF1, in addition to its well-known transactivating activities, mediates a genome-wide and massive histone deacetylation. Investigating the underlying mechanisms, we show that HSF1 specifically associates with and uses HDAC1 and HDAC2 to trigger this heat-shock-dependent histone deacetylation. This work therefore identifies HSF1 as a master regulator of global chromatin acetylation and reveals a cross-talk between HSF1 and histone deacetylases in the general control of genome organization in response to heat shock.

PMID:
19793920
PMCID:
PMC2785740
DOI:
10.1091/mbc.e09-04-0295
[Indexed for MEDLINE]
Free PMC Article

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