Format

Send to

Choose Destination
See comment in PubMed Commons below
Toxicology. 2010 Feb 9;268(3):143-6. doi: 10.1016/j.tox.2009.09.014. Epub 2009 Sep 27.

Application of connectivity mapping in predictive toxicology based on gene-expression similarity.

Author information

1
Medical Research Council Toxicology Unit, University of Leicester, Systems Toxicology Group, Lancaster Road, Leicester, LE1 9HN, UK.

Abstract

Connectivity mapping is the process of establishing connections between different biological states using gene-expression profiles or signatures. There are a number of applications but in toxicology the most pertinent is for understanding mechanisms of toxicity. In its essence the process involves comparing a query gene signature generated as a result of exposure of a biological system to a chemical to those in a database that have been previously derived. In the ideal situation the query gene-expression signature is characteristic of the event and will be matched to similar events in the database. Key criteria are therefore the means of choosing the signature to be matched and the means by which the match is made. In this article we explore these concepts with examples applicable to toxicology.

PMID:
19788908
DOI:
10.1016/j.tox.2009.09.014
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center