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Eur J Ophthalmol. 2009 Sep-Oct;19(5):824-30.

Toxoplasmic retinochoroiditis in an Italian referral center.

Author information

1
Dipartimento di Scienze Oftalmologiche, Servizio di Immunovirologia Oculare, Università di Roma La Sapienza, Roma - Italy. massimo.accorinti@tiscali.it

Abstract

PURPOSE:

To evaluate the clinical features of ocular toxoplasmosis (OT).

METHODS:

Retrospective review of 3080 new patients with uveitis was performed to identify patients with active OT. The main outcome measures were ocular features and ocular complications.

RESULTS:

Active OT was diagnosed in 88 patients (2.85% of all uveitis), 39 male (44.3%) and 49 female (55.7%), at an average age of 20.4+/-14.6 years, lower than in other types of uveitis (p<0.0001). Acquired OT diagnosis was possible in 4 cases (4.5%), while in the others a differentiation between acquired or congenital OT was impossible. Unilateral OT occurred in 76 patients (86.36%), with lesions located inside the vascular arcade in 64 of them (84.2%). Among bilateral cases (12 patients, 13.63%), at least one lesion was central in 9 (75%). Isolated peripheral lesions were observed in 12 out of 88 patients (13.6%). During an average follow-up of 70+/-73.5 months, OT recurrences appeared in 70 patients (79.54%). Mean interval between diagnosis and first relapse was 43.57+/-48.46 months, while it shortened between subsequent relapses (24.44+/-26.5 months; p=0.001).

CONCLUSIONS:

Ocular toxoplasmosis is a highly recurrent disease, mainly unilateral, with an average age at onset lower than those observed in other types of uveitis. Time between relapses shortens significantly over time.

PMID:
19787604
[Indexed for MEDLINE]

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