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Med Care. 2009 Dec;47(12):1251-7. doi: 10.1097/MLR.0b013e3181b58b5c.

Active influenza vaccine safety surveillance: potential within a healthcare claims environment.

Author information

1
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA. jeff_brown@harvardpilgrim.org

Abstract

BACKGROUND:

Rapid safety assessment of novel vaccines, especially those targeted against pandemic influenza, is a public health priority.

OBJECTIVES:

Assess the feasibility of using healthcare claims data to rapidly detect influenza vaccine adverse events using sequential analytic methods.

RESEARCH DESIGN:

Retrospective pilot study simulating prospective surveillance using 6 cumulative monthly administrative claims data extracts. The first included encounters occurring in October; each subsequent extract included an additional month of encounters. Ten adverse events were evaluated, comparing postvaccination rates during the 2006-2007 influenza season to those expected based on rates observed in the prior season.

SUBJECTS:

Members of a large, multistate health insurer who had a claim for influenza vaccination during the 2005-2006 or 2006-2007 influenza seasons.

MEASURES:

The completeness of monthly claims extracts.

RESULTS:

Most vaccinations and outcomes were identified early in the 2006-2007 season; about 50% of vaccinations and short latency events were identified in the second monthly data extract, which would typically become available by mid-December, and 80% of vaccinations and events were identified in the third extract. With respect to overall claims lag, approximately 90% of vaccinations and events were identified within 1 to 2 months after vaccination, regardless of vaccination month.

CONCLUSIONS:

This study suggests that administrative claims data might contribute to same season influenza vaccine safety surveillance in large, defined populations, especially during a threat of pandemic influenza. Based on our previous work, we believe this method could be applied to multiple health plans' data to monitor a large portion of the US population.

PMID:
19786905
DOI:
10.1097/MLR.0b013e3181b58b5c
[Indexed for MEDLINE]

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