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Dig Liver Dis. 2010 Mar;42(3):175-8. doi: 10.1016/j.dld.2009.08.005. Epub 2009 Sep 27.

Prevalence of celiac disease in inflammatory bowel diseases: An IG-IBD multicentre study.

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1
Medical Department, Desio Hospital, Milan, Italy.

Abstract

BACKGROUND:

An association has been described in case reports between celiac disease and inflammatory bowel diseases. The aim of the present study is to assess the prevalence of celiac disease in a large series of Italian patients with inflammatory bowel disease.

METHODS:

The Italian Group for Inflammatory Bowel Disease conducted a multicentre study between January 2002 and December 2004, in which 22 gastroenterology centres in Italy enrolled 1711 consecutive outpatients with inflammatory bowel disease. 860 (50.2%) had Crohn's disease (415 females, mean age 40, range 18-75), 791 (46.2%) had ulcerative colitis (371 females, mean age 40, range 18-80), and 60 (3.5%) had indeterminate colitis (27 females, mean age 40, range 18-78). All patients underwent serological testing for anti-endomysial antibodies and anti-tissue transglutaminase antibodies; if positive upper GI endoscopy with duodenal biopsy was performed.

RESULTS:

Nine of the 1711 patients (0.5%) had serological and histological findings compatible with the diagnosis of celiac disease; six of them had ulcerative colitis and three had Crohn's disease.

CONCLUSIONS:

Overall we found a lower risk of celiac disease in our cohort of inflammatory bowel disease patients than in the general population; prevalence of celiac disease was higher in patients with ulcerative colitis than in those with Crohn's disease.

PMID:
19786375
DOI:
10.1016/j.dld.2009.08.005
[Indexed for MEDLINE]
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