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Protein Sci. 2009 Dec;18(12):2624-8. doi: 10.1002/pro.256.

MPEx: a tool for exploring membrane proteins.

Author information

1
Department of Physiology and Biophysics, Center for Biomembrane Systems, University of California, Irvine, California 92697-4560, USA.

Abstract

Hydropathy plot methods form a cornerstone of membrane protein research, especially in the early stages of biochemical and structural characterization. Membrane Protein Explorer (MPEx), described in this article, is a refined and versatile hydropathy-plot software tool for analyzing membrane protein sequences. MPEx is highly interactive and facilitates the characterization and identification of favorable protein transmembrane regions using experiment-based physical and biological hydrophobicity scales. Besides allowing the consequences of sequence mutations to be examined, it provides tools for aiding the design of membrane-active peptides. MPEx is freely available as a Java Web Start application from our web site at http://blanco.biomol.uci.edu/mpex.

PMID:
19785006
PMCID:
PMC2821280
DOI:
10.1002/pro.256
[Indexed for MEDLINE]
Free PMC Article

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