Send to

Choose Destination
Annu Rev Fluid Mech. 2009 Jan 1;41:91-107.

Hemodynamics of Cerebral Aneurysms.

Author information

Center for Computational Fluid Dynamics, George Mason University, Fairfax, Virginia 22030.


The initiation and progression of cerebral aneurysms are degenerative processes of the arterial wall driven by a complex interaction of biological and hemodynamic factors. Endothelial cells on the artery wall respond physiologically to blood-flow patterns. In normal conditions, these responses are associated with nonpathological tissue remodeling and adaptation. The combination of abnormal blood patterns and genetics predisposition could lead to the pathological formation of aneurysms. Here, we review recent progress on the basic mechanisms of aneurysm formation and evolution, with a focus on the role of hemodynamic patterns.

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center