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J Dent Res. 2009 Oct;88(10):894-903. doi: 10.1177/0022034509343143.

Sensitivity of salivary glands to radiation: from animal models to therapies.

Author information

1
Department of Nutritional Sciences, University of Arizona, 1177 E 4th St., Shantz 421,PO Box 210038, Tucson, AZ 85721, USA.

Abstract

Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals. Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in normal salivary glands, compare animal models used to investigate radiation-induced salivary gland damage, address therapeutic advances, and project future directions in the field.

PMID:
19783796
PMCID:
PMC2882712
DOI:
10.1177/0022034509343143
[Indexed for MEDLINE]
Free PMC Article

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