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Curr Opin Biotechnol. 2009 Oct;20(5):531-6. doi: 10.1016/j.copbio.2009.08.009. Epub 2009 Sep 23.

Optimizing mesenchymal stem cell-based therapeutics.

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  • 1Cell Targeting, Inc., 11000 Cedar Ave., Cleveland, OH 44106, USA.


Mesenchymal stem cell (MSC)-based therapeutics are showing significant benefit in multiple clinical trials conducted by both academic and commercial organizations, but obstacles remain for their large-scale commercial implementation. Recent studies have attempted to optimize MSC-based therapeutics by either enhancing their potency or increasing their delivery to target tissues. Overexpression of trophic factors or in vitro exposure to potency-enhancing factors are two approaches that are demonstrating success in preclinical animal models. Delivery enhancement strategies involving tissue-specific cytokine pathways or binding sites are also showing promise. Each of these strategies has its own set of distinct advantages and disadvantages when viewed with a mindset of ultimate commercialization and clinical utility.

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