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Clin Biochem. 2010 Jan;43(1-2):89-94. doi: 10.1016/j.clinbiochem.2009.09.011. Epub 2009 Sep 24.

Reference values for serum nitric oxide metabolites in an adult population.

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1
Endocrine Physiology Laboratory, Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, PO Box 19395-4763, Tehran, Iran.

Abstract

OBJECTIVES:

To determine reference values for serum nitric oxide metabolites (nitrite+nitrate=NO(x)) concentrations in adult subjects.

DESIGN AND METHODS:

Serum NO(x) concentration was measured, using the Griess method, in 694 non-smoking apparently healthy subjects, randomly selected from a population-based study. The International Federation of Clinical Chemistry guidelines and the robust method were used for determining reference values.

RESULTS:

The 95% reference values for serum NO(x) concentration and serum NO(x)/creatinine ratio were 11.5 to 76.4 micromol/L and 0.111 to 0.729 in men and 10.1 to 65.6 micromol/L and 0.121 to 0.777 in women, respectively. With increasing body mass index, upper limits of serum NO(x) and the NO(x)/creatinine ratio increased in women and decreased in men. Serum NO(x) levels above upper limits predicted both diabetes and metabolic syndrome in women.

CONCLUSIONS:

This study reports the first set of reference values for serum NO(x) concentration and NO(x)/creatinine ratio in a relatively large healthy non-smoking population.

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