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Res Microbiol. 2009 Nov;160(9):711-7. doi: 10.1016/j.resmic.2009.09.005. Epub 2009 Sep 22.

AAA proteases in mitochondria: diverse functions of membrane-bound proteolytic machines.

Author information

1
Institute for Genetics, Centre for Molecular Medicine (CMMC), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, D-50674 Cologne, Germany. t.tatsuta@uni-koeln.de

Abstract

FtsH/AAA proteases comprise a distinct family of membrane-bound, ATP-dependent proteases present in eubacteria and eukaryotic cells, where they are confined to mitochondria and chloroplasts. Here, we will summarize versatile functions of AAA proteases within mitochondria, which ensure mitochondrial integrity and cell survival, acting both as quality control and processing enzymes.

PMID:
19781639
DOI:
10.1016/j.resmic.2009.09.005
[Indexed for MEDLINE]

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