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Lancet. 1990 Nov 3;336(8723):1081-4.

Independent genetic determinants of pancreatic and pulmonary status in cystic fibrosis.

Author information

1
Department of Cystic Fibrosis, Royal Brompton and National Heart Hospital, London, UK.

Abstract

The concordance of pancreatic and pulmonary status among siblings with cystic fibrosis, the cystic fibrosis genotype, and non-genetic factors were analysed in adult patients with cystic fibrosis. Genetic factors were more important than non-genetic factors in affecting the severity of pancreatic and lung disease. The genetic factors were independent of each other and did not invariably cosegregate with specific mutations at the cystic fibrosis locus.

PMID:
1977977
DOI:
10.1016/0140-6736(90)92566-z
[Indexed for MEDLINE]

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