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Eur J Gastroenterol Hepatol. 2009 Dec;21(12):1433-5. doi: 10.1097/MEG.0b013e32832f5be4.

Acute hepatitis E infection associated with a false-positive serology against Epstein-Barr virus.

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AP-HP, Service d'Hépato-Gastroentérologie, Hôpital Antoine Béclère, Clamart, France.


Hepatitis E virus is a major cause of acute viral hepatitis. The diagnosis of acute viral hepatitis E is based essentially on antibodies and hepatitis E virus RNA. We describe herein a case of acute hepatitis E associated with a false-positive serology for Epstein-Barr virus (EBV). This case report suggests that anti-viral capsid antigen IgM must be interpreted with caution in acute E hepatitis. When positive, EBV RNA polymerase chain reaction can be useful as a false positivity of anti-viral capsid antigen IgM and can be misinterpreted as an acute infection. EBV false positivity was probably related to polyclonal stimulation of the immune system, favoured by hepatitis E.

[Indexed for MEDLINE]

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