Collagen is one of the fundamental building blocks of skin and plays a critical role in wound healing. This article looks at the wide array of collagen and living skin equivalent products containing collagen and living cells, and at how these may be used in the treatment of diabetic foot ulcers. Solid collagen, foamed collagen, living skin equivalents, and living cadaveric skin are considered. Clinical examples are included, along with a brief discussion of wound dressings that may help to enhance the incorporation of these materials.