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Org Lett. 2009 Oct 15;11(20):4748-51. doi: 10.1021/ol901961q.

Revealing substrate promiscuity of 1-deoxy-D-xylulose 5-phosphate synthase.

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  • 1Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Abstract

A study of DXP synthase has revealed flexibility in the acceptor substrate binding pocket for nonpolar substrates and has uncovered new details of the catalytic mechanism to show that pyruvate can act as both donor and acceptor substrate.

PMID:
19778006
PMCID:
PMC2761658
DOI:
10.1021/ol901961q
[PubMed - indexed for MEDLINE]
Free PMC Article
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