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Prenat Diagn. 2009 Dec;29(12):1103-8. doi: 10.1002/pd.2375.

Maternal serum placental protein 13 at 11-13 weeks of gestation in preeclampsia.

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1
Harris Birthright Research Centre, King's College Hospital, London SE5 9RS, UK.

Abstract

OBJECTIVE:

To examine the potential value of maternal serum concentration of placental protein 13 (PP13) at 11-13 weeks' gestation in screening for preeclampsia (PE).

METHODS:

Serum PP13, PAPP-A and uterine artery pulsatility index (PI) were determined in a case-control study of 208 cases that developed PE including 48 that required delivery before 34 weeks (early-PE) and 416 unaffected controls.

RESULTS:

Serum PP13 levels, expressed as multiples of the median (MoM) in the unaffected group, were significantly reduced in early-PE (0.83 MoM) but not in late-PE (0.96 MoM). In both early- and late-PE serum PAPP-A (0.55 and 0.84 MoM) was reduced and uterine artery PI (1.61 and 1.25 MoM) was increased. In PE pregnancies there was a significant association between serum PP13 and both uterine artery PI and serum PAPP-A (p < 0.0001 for both). Logistic regression analysis demonstrated that serum PP13 did not improve significantly the prediction of early-PE provided by a combination of maternal factors, uterine artery PI and PAPP-A.

CONCLUSION:

PP13 is implicated in the pathogenesis of impaired placentation and subsequent development of early-PE but measurement of this placental product is unlikely to be useful in screening for the disease at 11-13 weeks.

PMID:
19777530
DOI:
10.1002/pd.2375
[Indexed for MEDLINE]
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