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Beilstein J Org Chem. 2009 Jul 13;5:34. doi: 10.3762/bjoc.5.34.

Radical carbonylations using a continuous microflow system.

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1
Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.

Abstract

Radical-based carbonylation reactions of alkyl halides were conducted in a microflow reactor under pressurized carbon monoxide gas. Good to excellent yields of carbonylated products were obtained via radical formylation, carbonylative cyclization and three-component coupling reactions, using tributyltin hydride or TTMSS as a radical mediator.

KEYWORDS:

V-65; continuous flow system; microreactor; radical carbonylation; radical mediator

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