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FEBS Lett. 1990 Sep 17;270(1-2):127-31.

Cloning and structure of cDNA encoding alpha-latrotoxin from black widow spider venom.

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Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, Moscow.


cDNA encoding the putative alpha-latrotoxin precursor was isolated from spider venom glands cDNA library and sequenced. The cDNA contained the 4203 base-pair open reading frame corresponding to the 156,855-Da protein composed of 1401 amino acids. Computer analysis of the deduced primary structure revealed the presence of various internal imperfect repeats mainly in its central and C-terminal regions.

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