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Curr Opin Chem Biol. 2009 Dec;13(5-6):601-7. doi: 10.1016/j.cbpa.2009.08.015. Epub 2009 Sep 21.

Glycomics and disease markers.

Author information

1
Department of Chemistry, University of California, Davis, CA 95616, United States.

Abstract

Glycomics is the comprehensive study of all glycans expressed in biological systems. The biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl transferases. Glycosylation is therefore highly sensitive to the biochemical environment and has been implicated in many diseases including cancer. Recently, interest in profiling the glycome has increased owing to the potential of glycans for disease markers. In this regard, mass spectrometry is emerging as a powerful technique for profiling the glycome. Global glycan profiling of human serum based on mass spectrometry has already led to several potentially promising markers for several types of cancer and diseases.

PMID:
19775929
PMCID:
PMC2788081
DOI:
10.1016/j.cbpa.2009.08.015
[Indexed for MEDLINE]
Free PMC Article

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