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Bioorg Med Chem Lett. 2009 Nov 1;19(21):6200-4. doi: 10.1016/j.bmcl.2009.08.095. Epub 2009 Sep 3.

A naturally occurring brominated furanone covalently modifies and inactivates LuxS.

Author information

1
The Barnett Institute and the Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.

Abstract

Halogenated furanones, a group of natural products initially isolated from marine red algae, are known to inhibit bacterial biofilm formation, swarming, and quorum sensing. However, their molecular targets and the precise mode of action remain elusive. Herein, we show that a naturally occurring brominated furanone covalently modifies and inactivates LuxS (S-ribosylhomocysteine lyase, EC 4.4.1.21), the enzyme which produces autoinducer-2 (AI-2).

PMID:
19775890
PMCID:
PMC2760616
DOI:
10.1016/j.bmcl.2009.08.095
[Indexed for MEDLINE]
Free PMC Article

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