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Cell Microbiol. 2009 Nov;11(11):1579-86. doi: 10.1111/j.1462-5822.2009.01368.x. Epub 2009 Sep 23.

Salmonella--the ultimate insider. Salmonella virulence factors that modulate intracellular survival.

Author information

1
Laboratory of Intracellular Parasites, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, MT, USA.

Abstract

Salmonella enterica serovar Typhimurium is a common facultative intracellular pathogen that causes food-borne gastroenteritis in millions of people worldwide. Intracellular survival and replication are important virulence determinants and the bacteria can be found in a variety of phagocytic and non-phagocytic cells in vivo. Invasion of host cells and intracellular survival are dependent on two type III secretion systems, T3SS1 and T3SS2, each of which translocates a distinct set of effector proteins. However, other virulence factors including ion transporters, superoxide dismutase, flagella and fimbriae are also involved in accessing and utilizing the intracellular niche.

PMID:
19775254
PMCID:
PMC2774479
DOI:
10.1111/j.1462-5822.2009.01368.x
[Indexed for MEDLINE]
Free PMC Article

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