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Curr Opin Pharmacol. 2009 Dec;9(6):727-32. doi: 10.1016/j.coph.2009.08.009. Epub 2009 Sep 19.

MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma.

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Department of Surgery, Kyoto University Hospital, Shogoin, Kyoto City, Japan.


The molecular genetics of Barrett's esophagus (BE) and its evolution to esophageal adenocarcinoma (EAC) have been widely studied; however, the molecular mechanism of BE-EAC carcinogenesis has not been completely understood. MicroRNA (miRNA) is now essential to understand the molecular mechanism of cancer progression. Recent findings include the following: firstly, miRNA expression profiles can distinguish between BE and EAC; secondly, miR-196a is upregulated in EAC tissues targeting annexin A1, thereby exerting antiapoptotic effects and contributing to EAC cell survival; miR-196a may also constitute a good biomarker of progression during BE-EAC carcinogenesis; and thirdly, The miR-106b-25 polycistron is activated by genomic amplification and is involved in esophageal neoplastic progression and proliferation via the suppression of two target genes, p21 and Bim.

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