Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2009 Nov 1;19(21):6176-80. doi: 10.1016/j.bmcl.2009.09.006. Epub 2009 Sep 6.

Synthesis and structure-activity relationships of 2-(1,4'-bipiperidin-1'-yl)thiazolopyridine as H3 receptor antagonists.

Author information

1
Schering-Plough Research Institute, 2015 Galloping Hill Road, K-15-1-1800, Kenilworth, NJ 07033, USA. ashwin.rao@spcorp.com

Abstract

A series of 2-(1,4'-bipiperidine-1'-yl)thiazolopyridines was synthesized and evaluated as a new lead of non-imidazole histamine H(3) receptor antagonists. Introduction of diversity at the 6-position of the pyridine ring was designed to enhance in vitro potency and decrease hERG activity. The structure-activity relationships for these new thiazolopyridine antagonists are discussed.

PMID:
19773164
DOI:
10.1016/j.bmcl.2009.09.006
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center