Format

Send to

Choose Destination
Zhong Yao Cai. 2009 May;32(5):740-4.

[Flavonoids from Diospyros kaki inhibit the adhesion between lymphocyte and dorsal root ganglion].

[Article in Chinese]

Author information

1
Guangzhou Pharmaceutical University, The Institute of Chinese Medicinal Sciences, Guangzhou 510006, China. bei-wj2000@yahoo.com.cn

Abstract

OBJECTIVE:

To investigate the effects of flavonoids from the leaves of Diospyros kaki L (FLDK) on the adhesion between the lymphocyte and the neurone.

METHODS:

Centrifugal assay for fluorescence-bsaed cell adhesion was used to assay the adhesion between the lymphocyte and the dorsal root ganglion (DRG).

RESULTS:

The adhesion was significantly suppressed in the presence of FLDK dose-dependently at 5, 25 microg/mL concentration. FLDK was also effective to inhibit the adhesion under the challenge of ICAM-1 by 28.5% and 50.1%, respectively. Furthermore, FLDK enforced the inhibition of anti-NCAM antibody on the lymphocyte adhesion to DRG cells.

CONCLUSION:

FLDK might contribute to the prevention and treatment of the inflammation injury under neuron insult such as ischemia/reperfusion, neurotrauma and other neurodegenerative disease by inhibiting the adhesion between lymphocytes and neurons.

PMID:
19771850
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center