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Nature. 1990 Oct 4;347(6292):477-9.

Two components of long-term potentiation induced by different patterns of afferent activation.

Author information

1
Neurobiology Department, Northeastern Ohio Universities College of Medicine, Rootstown 44272.

Abstract

Long-term potentiation (LTP) of excitatory synaptic transmission could be a mechanism underlying memory. Induction of LTP requires Ca2+ influx into postsynaptic neurons through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in hippocampus (area CA1 and dentate gyrus) and neocortex. Here we report that a component of LTP not requiring the activation of NMDA receptors can be induced in area CA1. The component is dependent on tetanus frequency, requires increases in postsynaptic intracellular Ca2+ concentrations, and is suppressed by an antagonist of voltage-dependent Ca2+ channels.

PMID:
1977084
DOI:
10.1038/347477a0
[Indexed for MEDLINE]

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