Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Endocrinol Diabetes Obes. 2009 Dec;16(6):430-4. doi: 10.1097/MED.0b013e328331dca2.

Disorders of the growth plate.

Author information

1
Department of Pediatrics, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA. Chanika_Phornphutkul@brown.edu

Abstract

PURPOSE OF REVIEW:

To summarize the recent advances in our understanding of the majors genes involved in chondrogenesis and their molecular mechanisms.

RECENT FINDINGS:

Disorders of the growth plate and the resulting skeletal dysplasias are a consequence of defects in genes involved in various stages of the chondrocyte proliferation and differentiation process. Recent identification of disease genes has provided insights into the pathophysiology of many skeletal dysplasias.

SUMMARY:

This knowledge enhances our understanding of the physiology and pathophysiology of the growth plate. Many skeletal dysplasias can now be characterized at the molecular level, allowing clinicians to provide accurate molecular diagnoses and counseling. Further research in this area will likely provide insights into possible therapeutic options for disorders of the growth plate.

PMID:
19770649
PMCID:
PMC2894809
DOI:
10.1097/MED.0b013e328331dca2
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wolters Kluwer Icon for PubMed Central
    Loading ...
    Support Center