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Res Microbiol. 2009 Nov;160(9):684-6. doi: 10.1016/j.resmic.2009.08.015. Epub 2009 Sep 19.

Temperature-dependent proteolysis as a control element in Escherichia coli metabolism.

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Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel Aviv University, Levanon St, Tel Aviv 69978, Israel.


Escherichia coli can grow at a broad temperature range, from less than 20 degrees C up to 45 degrees C. An increase in temperature results in a major physiological change, as enzymes work faster but, on the other hand, proteins tend to unfold. Therefore, a shift-up in temperature results in the induction of several regulatory response mechanisms aimed at restoring balanced growth at the new temperature. One important mechanism involves temperature-dependent proteolysis, which constitutes a fast response to temperature shift-ups. Here we discuss the effect of proteolysis on protein synthesis, and the heat shock response.

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