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FEBS Lett. 2009 Dec 17;583(24):3900-4. doi: 10.1016/j.febslet.2009.09.031.

Metabolic systems biology.

Author information

1
Department of Bioengineering, UCSD, La Jolla, CA 92093-0412, USA. palsson@ucsd.edu

Abstract

The first full genome sequences were established in the mid-1990s. Shortly thereafter, genome-scale metabolic network reconstructions appeared. Since that time, we have witnessed an exponential growth in their number and uses. Here I discuss, from a personal point of view, four topics: (1) the placement of metabolic systems biology in the context of broader scientific developments, (2) its foundational concepts, (3) some of its current uses, and (4) some of the expected future developments in the field.

PMID:
19769971
PMCID:
PMC3119668
DOI:
10.1016/j.febslet.2009.09.031
[Indexed for MEDLINE]
Free PMC Article
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