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Nat Genet. 2009 Oct;41(10):1058-60. doi: 10.1038/ng.452. Epub 2009 Sep 20.

Multiple loci on 8q24 associated with prostate cancer susceptibility.

Collaborators (525)

Bollina P, Bonnington S, Cooper D, Doble A, Doherty A, Durkan G, Elliott E, Gillatt D, Herbert P, Holding P, Howson J, Jones M, Kockelbergh R, Kynaston H, Lennon T, Lyons N, Leung H, Moody H, Powell P, Prescott S, Thompson P, Durkan G, Brown PM, George A, Marsden G, Davis M, Cohen NP, Conn I, Swami KS, Moffat LE, Kenwrick S, Patterson H, Waite K, Doble A, Wiles V, Irwin C, Lancashier M, Ellis BW, Kulkarni R, Gurun RM, Hollins GW, Mahmood R, Meddings RN, Briggs T, Chong I, Gelister JS, Mumtaz F, Ravi R, Malone PR, Pengelly A, Dodds D, Featherston C, Hendry D, Jones G, Kirk D, Russell JM, Siva M, Leader M, Thomas RJ, Morrison P, O'Sullivan J, Shum L, Stewart D, Feggetter J, O'Brien J, Cole T, Cruger D, Maher ER, Neilson D, Wemyss-Holden GD, Susnerwala S, Bahl A, Persad R, Wright M, Zang A, Leone P, Tahir S, Parikh O, Virdi J, Izegbu V, Bellringer J, Christmas TJ, Falconer A, Carter S, Hrouda D, Karp SJ, Bower M, Dinneen M, Brock C, Gilbert H, Jenkins P, Boucher NR, James MJ, Cowan R, Evans DG, Livsey J, Logue J, Wylie JP, Lalloo F, Sugden E, Brewster SF, Cole DJ, Connell C, Protheroe A, Saxby MF, Ryan PG, Peake D, Coe M, Errington RD, Ibrahim A, Syndikus I, Booth CM, Corr J, Lynch M, Callaghan PS, Plail R, Ash D, Coyle C, Bottomley D, Powell C, Chilton C, Henley M, Peracha AM, Williams JH, Williams S, Muthukumar D, Thomas SA, Dickinson AJ, Hammonds J, McInerney P, Pascoe S, Sells H, Tyrell CJ, Tindall SF, Afzal N, Andrews S, Cornaby AJ, Archbold JA, Kunkler IH, Folkes A, Money-Kyrle J, Bax NA, Lawrence WT, McKinna F, Rimington PR, Dawson C, Khan F, Charig C, Le Roux PJ, Hehir M, Smith MF, Tweedle J, Glenister J, Eden CD, Langley SE, Montgomery B, Naerger H, Palfrey E, Wilson R, Qureshi KN, Apakama I, Prasad K, Al-Samerraie, Emmerson L, Nethersell A, Srinivasan, Glaholm J, Ohja H, Dahar N, Daruwala P, Beck R, Iacovou JW, Harper P, Perry M, Popert R, Cahill D, Dobbs HJ, Izatt L, O'Brien TS, Tong, Kelkar AR, Waxman JH, Badenoch D, O'Donoghue N, Singh P, Lawson A, Pancharatnam M, Shah N, Sole GM, Pope AJ, Clarke NW, Ferro M, Harney JM, Douglas SF, Banerjee G, Donaldson P, Scrase C, Chadwick D, Hardman PD, Hindmarsh JR, Suresh G, Mithal N, Murray KW, Davison OW, Baxter-Smith D, Motiwala H, Barber N, Muir G, Copland RF, Dick J, Morley R, Thompson A, Van As N, Butterworth PC, Griffiths TR, Kockelbergh R, Osborn D, Terry T, Barwell J, Trembath RC, Javle P, Basu P, Mark I, Panades M, Sreenivasan T, Hanbury D, McNicholas TA, Davidson S, Holden D, Namasivayam S, Reddy PJ, Beesley S, Ford TF, Lewis J, Chetiyawardana AD, Smith J, Mufti G, Andrews H, Walker EM, Anjum I, Bose P, Lucas MG, Ashford RF, Dickson J, Hoskin P, Hughes R, Ostler P, Churn MJ, Cooke P, Inglis JA, Philp NH, Waymont B, Leung H, McMenemin R, Pedley I, Roberts JT, Lee JO, Ho ET, Irving S, Mills R, Sethia KK, Webb RJ, Sheehan DJ, Barnes DG, Chow WM, Costello CB, Elwell C, Elkabir J, Fermont D, Mee AD, Bishop M, Cole O, Harriss DR, Lemburger RJ, Sokal M, Sundar S, Dunn M, Urwin GH, Benson R, Baria, Memon, Biyani CS, Browning TJ, Murphy M, Sundaram SK, Weston PM, Goode TD, Hickish T, Castle BM, Cummings, Eccles D, Harvey-Hills N, Mort D, Menzes P, Ahmed M, Dawkins G, Bhatt RI, Doherty A, El-Modir A, Hughes M, Luscombe CJ, Wallace DM, James N, Subramonian K, Hampson SJ, Gibbs S, Chakraborti P, Kumar M, Whillis D, Kourah M, Parys B, Lau MW, Brown R, Fawcett D, Rogers PB, Lee L, Mobb GE, Pantelides ML, Bramble FJ, Brock S, Carter CJ, Davies J, McBride D, Rundle J, Wedderburn A, Collinson M, Cox R, Ellis R, Newton R, O'Rourke JS, Thomson AH, Wheatley D, Stott MA, Pocock RD, Rankin J, Crundwell M, Kaisary A, Pigott K, Bates CA, Beese G, Bowsher WG, Carter AC, Gower RL, Hamdy FC, Anderson J, Harrison GS, Adamson A, Duffy P, Rowbotham C, Woolfenden KA, Cornford PA, Bancroft E, Dearnaley D, Huddart R, Jhavar S, Khoo V, Locke I, Mitra A, Parker C, Shanley S, Woodhouse C, Wynne C, Horwich A, Ogden C, Sharma NK, Birtle A, Mokete, Ragavan N, Read, Watson ME, Wise M, Blades R, Matenhelia S, Beacock C, Elves AW, Srihari NN, Birch B, Heath CM, Laing R, Bloomfield DJ, Coker C, Deutsch GP, Fletcher M, Larner TR, Murrell S, Nawrocki, Robinson A, Wilkins M, Frim O, Gallegos C, Howell GP, McFarlane J, Newman H, Samanci A, Campbell A, Guy PJ, McIntosh G, Hamilton C, Hawkyard S, Robertson A, Coombs L, Dixit S, Morris SB, Ball AJ, Carr TW, Koreich O, Lodge R, Prejbisz JW, Robinson AC, Abrams PH, Corolis, Drake, Gillatt D, Graham J, Rowe, Keeley FX, McGrath, Schwaibold H, Vesey S, Thurston A, Watkin NA, Chinegwundoh FI, Lee A, Mair GH, Nargund V, Oliver T, Plowman N, Anson K, Hodgson S, Saggar AK, Bailey MJ, Gordon EM, Taylor JW, Boyd PJ, Jones CR, Walker R, Joss S, Whelan P, Aparcia F, Hudson L, Prescott S, Patel A, Holmes SA, Dunsmuir WD, Beaney RP, Calman F, Glass JM, Simcock R, James RL, Rao Y, Scoble JE, Adeyoju A, Brown S, Collins G, Oakley N, O'Reilly P, Lloyd S, Alcock C, Greenland J, Green D, Brough R, O'Boyle PJ, Macdonagh RP, Speakman MJ, Violet J, Mostafid AH, Kirby RS, Kirollos MM, Lydon A, MacDermott JP, Mason R, Carnell DM, Emberton M, Harland SJ, O'Donoghue E, Payne H, Duchesne GM, Blacklock AR, Desai KM, Grieve R, Humber C, Sriram R, Stockdale A, Willis M, Worlding J, Bailey K, Murray A, Datta S, Hughes O, Kynaston H, Matthews PN, Barber J, Lester J, Mason MD, Rowley K, Tilsley O, Longmuir M, Robinson LQ, Jones DA, Lewis DC, Strachan JR, Crisp JC, Mitchell S, Sherwin E, McLaren D, Taylor JW, Tulloch DN, Ferguson C, Kirkbride P, Brown R, Karim O, Laniado M, Philp T, Wells P, Beard R, Liston T, Woodhams S, De Bolla AR, Kelleher JP, Weaver A, Parker CH, Porter T, Stower MJ, Wilson JR, Ahiaku EK.

Abstract

Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.

PMID:
19767752
DOI:
10.1038/ng.452
[Indexed for MEDLINE]

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