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J Bacteriol. 2009 Nov;191(22):7123-8. doi: 10.1128/JB.00731-09. Epub 2009 Sep 18.

A 5' leader sequence regulates expression of methanosarcinal CO dehydrogenase/acetyl coenzyme A synthase.

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1
Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 E. Pratt St., Baltimore, MD 21202, USA.

Abstract

In vivo expression of CO dehydrogenase/acetyl coenzyme A synthase in Methanosarcina spp. is coordinately regulated in response to substrate by at least two mechanisms: differential transcription initiation and early elongation termination near the 3' end of a 371-bp leader sequence. This is the first report of regulation of transcription elongation in the Archaea.

PMID:
19767426
PMCID:
PMC2772459
DOI:
10.1128/JB.00731-09
[Indexed for MEDLINE]
Free PMC Article
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