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J Neuroimmunol. 2009 Nov 30;216(1-2):92-7. doi: 10.1016/j.jneuroim.2009.08.013. Epub 2009 Sep 19.

TNF-alpha and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects.

Author information

1
New York University, College of Dentistry, Department of Periodontology and Implant Dentistry, New York, NY 10010, USA. ark5@nyu.edu

Abstract

The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-alpha and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical diagnosis of AD. Plasma TNF-alpha and antibodies against periodontal bacteria were elevated in AD patients compared with NL and independently associated with AD. The number of positive IgG to periodontal bacteria incremented the TNF-alpha classification of clinical AD and NL. This study shows that TNF-alpha and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis.

PMID:
19767111
PMCID:
PMC2783848
DOI:
10.1016/j.jneuroim.2009.08.013
[Indexed for MEDLINE]
Free PMC Article
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