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Mol Cell Endocrinol. 2010 May 28;321(1):36-43. doi: 10.1016/j.mce.2009.09.013. Epub 2009 Sep 18.

Mechanisms of chromosomal rearrangements in solid tumors: the model of papillary thyroid carcinoma.

Author information

1
Department of Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Abstract

Thyroid cancer, and its most common type, papillary carcinoma, frequently have chromosomal rearrangements and therefore represent a good model for the understanding of mechanisms of chromosomal rearrangements in solid tumors. Several types of rearrangement known to occur in thyroid cancer, including RET/PTC, NTRK1 and BRAF/AKAP9, are more common in radiation-associated thyroid tumors and RET/PTC can be induced experimentally by exposing human thyroid cells to ionizing radiation. In this review, the molecular mechanisms of generation of RET/PTC and other chromosomal rearrangements are discussed, with the emphasis on the role of nuclear architecture and interphase gene proximity in the generation of intrachromosomal rearrangements in thyroid cells.

PMID:
19766698
PMCID:
PMC2849910
DOI:
10.1016/j.mce.2009.09.013
[Indexed for MEDLINE]
Free PMC Article

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