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Trends Immunol. 2009 Oct;30(10):488-93. doi: 10.1016/j.it.2009.07.006. Epub 2009 Sep 18.

Esterases and autoimmunity: the sialic acid acetylesterase pathway and the regulation of peripheral B cell tolerance.

Author information

1
Cancer Center, Massachusetts General Hospital, Boston MA 02129, USA. pillai@helix.mgh.harvard.edu

Abstract

The best studied mechanisms of B cell tolerance are receptor editing, clonal deletion and anergy. All of these mechanisms of B cell tolerance depend on the induction of signaling downstream of the B cell receptor by self-antigens. Another important and distinct mechanism of B cell tolerance involves the repression of antigen receptor signaling rather than its induction, utilizes the Lyn Src-family kinase, the SHP-1 tyrosine phosphatase, inhibitory members of the Siglec family, and a carbohydrate-modifying enzyme that is capable of negatively regulating B cell receptor activation known as sialic acid acetylesterase.

PMID:
19766537
PMCID:
PMC2758290
DOI:
10.1016/j.it.2009.07.006
[Indexed for MEDLINE]
Free PMC Article

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