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Diagn Microbiol Infect Dis. 2009 Dec;65(4):439-46. doi: 10.1016/j.diagmicrobio.2009.08.005. Epub 2009 Sep 18.

Diversity of the bla(SHV) genes.

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Antibiotic Resistance Unit, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, 1649-016 Lisbon, Portugal.


We investigated the diversity of nucleotide sequences of 297 SHV-encoding genes, based on nucleotide synonymous mutations and the presence or absence of the nonsynonymous mutation T92A. The analysis of this diversity allowed us to develop and propose a classification to differentiate the nucleotide sequence variants of the bla(SHV) genes.

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