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Semin Cell Dev Biol. 2009 Dec;20(9):1107-13. doi: 10.1016/j.semcdb.2009.09.005. Epub 2009 Sep 16.

Scratching the niche that controls Caenorhabditis elegans germline stem cells.

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1
Department of Biochemistry and Howard Hughes Medical Institute, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706-1544, USA. dbyrd@wisc.edu

Abstract

The Caenorhabditis elegans gonad provides a well-defined model for a stem cell niche and its control of self-renewal and differentiation. The distal tip cell (DTC) forms a mesenchymal niche that controls germline stem cells (GSCs), both to generate the germline tissue during development and to maintain it during adulthood. The DTC uses GLP-1/Notch signaling to regulate GSCs; germ cells respond to Notch signaling with a network of RNA regulators to control the decision between self-renewal and entry into the meiotic cell cycle.

PMID:
19765664
PMCID:
PMC2820558
DOI:
10.1016/j.semcdb.2009.09.005
[Indexed for MEDLINE]
Free PMC Article
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