Format

Send to

Choose Destination
See comment in PubMed Commons below
PLoS Genet. 2009 Sep;5(9):e1000658. doi: 10.1371/journal.pgen.1000658. Epub 2009 Sep 18.

Broad-scale recombination patterns underlying proper disjunction in humans.

Author information

1
Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America.

Abstract

Although recombination is essential to the successful completion of human meiosis, it remains unclear how tightly the process is regulated and over what scale. To assess the nature and stringency of constraints on human recombination, we examined crossover patterns in transmissions to viable, non-trisomic offspring, using dense genotyping data collected in a large set of pedigrees. Our analysis supports a requirement for one chiasma per chromosome rather than per arm to ensure proper disjunction, with additional chiasmata occurring in proportion to physical length. The requirement is not absolute, however, as chromosome 21 seems to be frequently transmitted properly in the absence of a chiasma in females, a finding that raises the possibility of a back-up mechanism aiding in its correct segregation. We also found a set of double crossovers in surprisingly close proximity, as expected from a second pathway that is not subject to crossover interference. These findings point to multiple mechanisms that shape the distribution of crossovers, influencing proper disjunction in humans.

PMID:
19763175
PMCID:
PMC2734982
DOI:
10.1371/journal.pgen.1000658
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Support Center