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Anesth Analg. 2009 Oct;109(4):1279-83. doi: 10.1213/ane.0b013e3181b0f0bb.

A comparison of intravenous oxycodone and intravenous morphine in patient-controlled postoperative analgesia after laparoscopic hysterectomy.

Author information

1
University of Oslo, Faculty Division Ullevaal University Hospital, Oslo, Norway. harald.lenz@medisin.uio.no

Abstract

INTRODUCTION:

In this study, we investigated the dose requirements, pain relief, and side effects of oxycodone versus morphine after surgery with visceral pain.

METHODS:

Ninety-one women received IV oxycodone or morphine before the end of laparoscopic hysterectomy and then continued with patient-controlled analgesia for 24 h postoperatively.

RESULTS:

The accumulated oxycodone consumption was less (13.3 +/- 10.4 mg vs 22.0 +/- 13.1 mg, P = 0.001) than morphine. With oxycodone, the visual analog scale scores were significantly lower in the first hour postoperatively and sedation was less during the 24-h postoperative period, P = 0.006.

CONCLUSIONS:

Oxycodone was more potent than morphine for visceral pain relief but not for sedation.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00528177.

PMID:
19762758
DOI:
10.1213/ane.0b013e3181b0f0bb
[Indexed for MEDLINE]

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