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Bioorg Med Chem. 2009 Oct 15;17(20):7337-43. doi: 10.1016/j.bmc.2009.08.035. Epub 2009 Aug 21.

The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.

Author information

1
Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA.

Abstract

In order to improve metabolic stability, a ring structure with a cystine moiety was introduced into TY027 (Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-[3',5'-(CF(3))(2)Bzl]), which is a lead compound of our developing bifunctional peptide possessing opioid agonist and NK1 antagonist activities. TY038 (Tyr-cyclo[D-Cys-Gly-Phe-Met-Pro-D-Cys]-Trp-NH-[3',5'-(CF(3))(2)Bzl]) was found as a highly selective delta opioid agonist over mu receptor in conventional tissue-based assays, together with an effective NK1 antagonist activity and good metabolic stability with more than 24h half life in rat plasma.

PMID:
19762245
PMCID:
PMC2775479
DOI:
10.1016/j.bmc.2009.08.035
[Indexed for MEDLINE]
Free PMC Article

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