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J Am Coll Cardiol. 2009 Sep 22;54(13):1123-30. doi: 10.1016/j.jacc.2009.04.089.

Regadenoson: a new myocardial stress agent.

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Department of Medicine, The University of Alabama at Birmingham, USA.

Erratum in

  • J Am Coll Cardiol. 2009 Oct 20;54(17):1635.


Vasodilator stress myocardial perfusion imaging (MPI) accounts for up to 50% of all stress MPI studies performed in the U.S. In 2008, the Food and Drug Administration approved regadenoson for stress testing in conjunction with MPI. Regadenoson, unlike adenosine, is a selective A(2A) agonist that is given as an intravenous bolus at a fixed dose, with less undesirable side effects including atrioventricular block and bronchospasm. Unlike adenosine, regadenoson could be used in patients with mild-to-moderate reactive airway disease. This review will summarize the pre-clinical and clinical data on regadenoson, as they specifically relate to its use as a vasodilator stress agent, currently the only approved selective A(2A) agonist.

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