Format

Send to

Choose Destination
See comment in PubMed Commons below
BMC Med. 2009 Sep 16;7:48. doi: 10.1186/1741-7015-7-48.

Human cellular restriction factors that target HIV-1 replication.

Author information

  • 1Laboratory of Molecular Microbiology, NIAID, the National Institutes of Health, Bethesda, Maryland, USA.

Abstract

Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5alpha), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions.

PMID:
19758442
PMCID:
PMC2759957
DOI:
10.1186/1741-7015-7-48
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Support Center