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Jpn J Cancer Res. 1990 Aug;81(8):727-30.

Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord.

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Department of Pathology, University of Tokyo.


This communication describes the cellular and ultrastructural localization in the central nervous system of P-glycoprotein (P-GP) recognized by a murine monoclonal antibody, MRK 16. At the ultrastructural level P-GP was strictly confined to the luminal surface of the endothelial cells which comprise the capillary vessels of the brain and the spinal cord. No P-GP was found in the endothelial cells of other organs. Our findings may be useful as a means to define the blood-brain barrier, and they imply that the blood-brain barrier is anatomically characterized by the presence of intercellular tight junctions between continuous nonfenestrated endothelial cells.

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