Sexually transmitted infections (STIs) continue to be a great concern in the adolescent population and of particular concern to the pediatric emergency medicine physician. The Centers for Disease Control and Prevention reports that rates of gonorrheal and chlamydial infections are greatest in female adolescents, aged 15 to 19 years, and many people acquire human papilloma virus and human immunodeficiency virus infections during their teenage years. Adolescents continue to be at a higher risk for acquiring STIs because of multiple factors, including being more biologically susceptible, more likely to engage in unprotected sex with multiple partners, as well as facing various obstacles to their use of the health care system. The pediatric emergency medicine physician must be aware of the various presentations of STIs in their patients, as well as how to adequately treat and offer counseling to this vulnerable population.