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Cell Cycle. 2009 Oct 1;8(19):3112-9.

Exploiting synthetic lethal interactions for targeted cancer therapy.

Author information

1
The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

Abstract

Emerging data suggests that synthetic lethal interactions between mutated oncogenes/tumor suppressor genes and molecules involved in DNA damage signaling and repair can be therapeutically exploited to preferentially kill tumor cells. In this review, we discuss the concept of synthetic lethality, and describe several recent examples in which this concept was successfully implemented to target tumor cells in culture, in mouse models, and in human cancer patients.

PMID:
19755856
PMCID:
PMC3057180
DOI:
10.4161/cc.8.19.9626
[Indexed for MEDLINE]
Free PMC Article

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