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EuroIntervention. 2006 Nov;2(3):318-25.

Catheter closure of paravalvular leak.

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CardioVascular Center Frankfurt, Sankt Katharinen, Frankfurt, Germany.



The purpose of this study was to evaluate the feasibility and short-term efficacy of transcatheter paravalvular leak closure using different occlusion devices.


Twenty-one patients underwent transcatheter closure of either aortic or mitral paravalvular leak from June 2002 to February 2006 using the Amplatzer PDA, ASD or VSD occluder. All patients had symptoms and signs of haemolysis and/or cardiac decompensation with dyspnoea.Implantation of a device was technically successful in twenty patients (95%). Immediate residual leak was found in seventeen patients (85%). Significant shunting persisted in nine cases during follow up (45%).Permanent leaflet obstruction was observed in one patient. Severe complications during follow up led to early death in one patient and surgical intervention in three. A successful second catheter treatment was performed in another three patients. The event-free survival from re-operation, death and stroke at the end of the observation period was 80%.


Transcatheter closure of paravalvular leaks is a technically feasible, but demanding procedure. Residual leaks are common and may worsen pre-existing haemolysis. Due to the significant ongoing morbidity in this group of patients and the complexity of follow up individual patient results differ considerably. Nevertheless, it is possible to achieve some symptomatic relief, thus an interventional approach should be discussed as a potential treatment option for those patients with a limited defect and who are not deemed suitable for another operation.


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